O'Dwyer Lung Lab

View Dr. O’Dwyer’s Pubmed profile here

see our most recent work

• Toll-like receptor 5 protects against murine lung fibrosis through reduced dysbiosis, and TLR5 deficiency is associated with human IPF – Science Translational Medicine (2026)

• Gut microbiota associate with disease severity and survival in idiopathic pulmonary fibrosis – AJRCCM (2026)

• Targeted lung Lactobacillus johnsonii intervention alleviates virus-induced fibrosis post-HCT through PD-L1/PD-1 signaling – Science Advances (2026)

• A Quantitative Imaging Measure of Progressive Pulmonary Fibrosis – AJRCCM (2025)

• Addressing Knowledge Gaps in the Early Detection of Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation: An Official American Thoracic Society Research Statement – AJRCCM (2025)

• Residual interstitial lung abnormalities post-COVID-19 infection appear independent of lung microbiota – ERJ Open Research (2025)

• The Lung Microbiome In Interstitial Lung Disease – Review, Breathe (2025)

• STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis – JCI Insight (2024)

• The Oral-Lung Microbiome Axis in Connective Tissue Disease-Related Interstitial Lung Disease – Review, Seminars in Respiratory and Critical Care Medicine (2024)

• The Lung Microbiome – Review, Journal of Immunology (2024)

• Commensal Oral Microbiota, Disease Severity, and Mortality in Fibrotic Lung Disease – AJRCCM (2024)

• Horizontal Transmission of Gut Microbiota Attenuates Mortality in Lung Fibrosis – JCI Insight (2023)

• “It’s getting hot in here: the interface between obesity, influenza and thermoneutrality” – Editorial, Mucosal Immunology (2023)

• Fibrotic Lung Disease Alters Neutrophil Trafficking and Promotes Neutrophil Elastase and Extracellular Trap Release – ImmunoHorizons (2022)

• Myeloid- and Epithelial-derived Heparin-Binding Epidermal Growth Factor-like Growth Factor Promotes Pulmonary Fibrosis – AJRCMB (2022)

• Hypothyroidism Is Associated with Increased Mortality in Interstitial Pneumonia with Autoimmune Features – Annals of the American Thoracic Society (2022)

• Therapeutic Targeting of the Respiratory Microbiome – AJRCCM (2022)

• Toll-Interacting Protein and Altered Lung Microbiota in Idiopathic Pulmonary Fibrosis – AJRCCM (2022)

• Fibrotic lung disease inhibits immune responses to staphylococcal pneumonia via impaired neutrophil and macrophage function – JCI Insight (2022)

• Candidate Role for Toll-like Receptor 3 L412F Polymorphism and Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis – AJRCCM (2022)

• Pretransplant Antifibrotic Therapy Is Associated with Resolution of Primary Graft Dysfunction – Annals of the American Thoracic Society (2022)

• Toll-like receptors, environmental caging, and lung dysbiosis – AJP Lung (2021)

• Concurrent Reductions in Spirometry Predict Mortality and Bronchiolitis Obliterans in Chronic Graft-versus-Host Disease – Annals of the American Thoracic Society (2021)

• The Lung Microbiome in Health, Hypersensitivity Pneumonitis, and Idiopathic Pulmonary Fibrosis: A Heavy Bacterial Burden to Bear – Editorial, AJRCCM (2021)

• The evolving role of the lung microbiome in pulmonary fibrosis – Review, AJP Lung (2020)

• Identification of a unique temporal signature in blood and BAL associated with IPF progression – Scientific Reports (2020)

• Methods in Lung Microbiome Research – Review, AJRCMB (2020)

• Radiographic Honeycombing and Altered Lung Microbiota in Patients with Idiopathic Pulmonary Fibrosis – AJRCCM (2019)

• Ironing Out the Roles of Macrophages in Idiopathic Pulmonary Fibrosis – Editorial, AJRCCM (2019)

• Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis – AJRCCM (2019)

• First-Onset Herpesviral Infection and Lung Injury in Allogeneic Hematopoietic Cell Transplantation – AJRCCM (2019)

• Proteomics: Clinical and research applications in respiratory diseases – Review, Respirology (2018)

• Animal Models of Pulmonary Fibrosis – Protocol, Methods in Molecular Biology (2018)

• Lung Dysbiosis, Inflammation, and Injury in Hematopoietic Cell Transplantation – AJRCCM (2018)

• Pulmonary immunity and extracellular matrix interactions – Review, Matrix Biology (2018)

• The role of periostin in lung fibrosis and airway remodeling – Review, Cellular and Molecular Life Sciences (2018)

• Host-Microbial Interactions: Idiopathic Pulmonary Fibrosis in Technicolor – Editorial, AJRCCM (2017)

• The peripheral blood proteome signature of idiopathic pulmonary fibrosis is distinct from normal and is associated with novel immunological processes – Scientific Reports (2017)

• Six-SOMAmer Index Relating to Immune, Protease and Angiogenic Functions Predicts Progression in IPF – PLoS One (2016)

• Influences of innate immunity, autophagy, and fibroblast activation in the pathogenesis of lung fibrosis – Review, AJP Lung (2016)

• Loss of CCR2 signaling alters leukocyte recruitment and exacerbates γ-herpesvirus-induced pneumonitis and fibrosis following bone marrow transplantation – AJP Lung (2016)

• The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease – Review, Journal of Immunology (2016)

• Targeting defective Toll-like receptor-3 function and idiopathic pulmonary fibrosis – Review, Expert Opinion on Therapeutic Targets (2015)

• The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis – AJRCCM (2013)

• Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD) – Review, European Journal of Internal Medicine (2013)